However, some people in the reviewed studies stopped taking bupropion due to the onset of psychiatric symptoms. This medication can help ease cravings and withdrawal symptoms as well as reduce the pleasurable effects of nicotine, making it less likely you’ll return to smoking.Ī 2020 review found that people who were taking bupropion were 52% to 77% more likely to quit smoking than those who used a placebo. Bupropion (Zyban, Wellbutrin)īupropion (Zyban, Wellbutrin) is an atypical antidepressant that acts as a dopamine and norepinephrine reuptake inhibitor. In 2021, the drugmaker Pfizer recalled Chantix due to high levels of nitrosamines, a potential cancer-causing compound, but FDA-approved generic versions of varenicline are still available. Research suggests that varenicline is the most effective monotherapy treatment for tobacco dependence. It works by partially activating the nicotine receptors in the brain, reducing the pleasurable effects of smoking and decreasing withdrawal symptoms. Varenicline (Chantix) was the first prescription medication developed specifically to help people quit smoking. The following medications are approved by the Food and Drug Administration (FDA) to help people quit smoking: Varenicline (Chantix) They may be a good option if NRT hasn’t worked for you in the past. Prescription oral medications, like varenicline and bupropion, can help manage cravings and withdrawal symptoms. One 2018 review of 133 studies that included 64,640 participants found that all forms of NRT can increase the rate of quitting by 50% to 60%. In particular, combining NRT approaches (for example, using both gum and a patch) improve success rates compared with using only one form. Research shows that different types of NRT are all equally effective for improving smoking abstinence rates and are comparable to the medication bupropion (Wellbutrin).
NRT provides a lower dose of nicotine so you’re able to wean your body off of nicotine in a gradual and controlled manner, making it easier to quit smoking. Some of these products, such as nicotine gum and patches, are available over the counter, while others, such as lozenges and inhalers, are prescription only. Nicotine replacement therapy (NRT) involves smoking cessation products that can help you manage nicotine cravings and withdrawal symptoms.
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